Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 6/20 | 0.40 |
| ▸ | TUBB | P07437 | 6/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.40 |
| ▸ | PTAFR | P25105 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719030 | 1.00 | TUBB4A (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719045 | 0.85 | PTAFR (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719053 | 0.85 | PTAFR (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719914 | 0.83 | ALDH1A1 (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719911 | 0.83 | ALDH1A1 (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719021 | 0.75 | PTAFR (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719110 | 0.75 | PTAFR (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719018 | 0.75 | PTAFR (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719096 | 0.73 | PTAFR (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719091 | 0.73 | PTAFR (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |