Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744359 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL9719027 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL15475932 | 0.82 | KMT2A (0.47) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL9719048 | 0.81 | SMN1; SMN2 (0.38) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL10040724 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL491076 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL17466005 | 0.77 | MEN1 (0.58) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL11436992 | 0.77 | KMT2A (0.46) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL22995348 | 0.77 | KMT2A (0.58) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL3458704 | 0.77 | ALDH1A1 (0.51) | ALDH1A1KMT2AMEN1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |