Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719027 | 0.84 | ALDH1A1 (0.52) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9719084 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9723254 | 0.77 | CCR1 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9719067 | 0.74 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9829357 | 0.73 | TUBB4A (0.41) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5744359 | 0.72 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9719059 | 0.72 | ALDH1A1 (0.34) | SMN1; SMN2MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL15475932 | 0.70 | KMT2A (0.47) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9719016 | 0.70 | ALDH1A1 (0.36) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9829388 | 0.69 | ALDH1A1 (0.48) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |