Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 11/20 | 0.37 |
| ▸ | TUBB | P07437 | 11/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 11/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 11/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 11/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 11/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 11/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 11/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 11/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 11/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 11/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 11/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 11/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 11/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 11/20 | 0.37 |
| ▸ | PTAFR | P25105 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719095 | 1.00 | LMNA (0.38) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9719014 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719122 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9724051 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719017 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9724049 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719881 | 0.90 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719107 | 0.79 | PTAFR (0.41) | PTAFR | |
| SCHEMBL10641571 | 0.79 | PTAFR (0.44) | PTAFR | |
| SCHEMBL9719887 | 0.79 | PTAFR (0.44) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257921-B1 | NEW 1,3-DIARYL CYCLOPENTANES AND DERIVATIVES THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |