Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.58 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.58 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10846145 | 0.85 | PDE10A (0.68) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL7716689 | 0.82 | PDE10A (0.63) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9719806 | 0.82 | PDE10A (0.63) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL10512475 | 0.80 | PDE10A (0.77) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL1695058 | 0.80 | CYSLTR1 (0.69) | PDE10ACYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8260654 | 0.80 | PDE10A (0.60) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL7460333 | 0.79 | CYSLTR1 (0.66) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL9719851 | 0.79 | MAOA (0.48) | — | |
| SCHEMBL9637029 | 0.78 | GPBAR1 (0.69) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 | |
| SCHEMBL8736559 | 0.77 | PDE10A (0.64) | PDE10ACYSLTR1GPBAR1CYSLTR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |