Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317653 | 0.90 | POLB (0.45) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL500044 | 0.89 | AKR1C3 (0.54) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL12499466 | 0.89 | AKR1C3 (0.54) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL7166547 | 0.89 | AKR1C3 (0.54) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL9719904 | 0.84 | MAPK1 (0.49) | L3MBTL1MAPK1KDM4EALDH1A1MAPT | |
| SCHEMBL16586360 | 0.82 | CYP2C19 (0.53) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL16585982 | 0.82 | CYP2C19 (0.53) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL16586030 | 0.81 | TDP1 (0.43) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A | |
| SCHEMBL16586138 | 0.81 | HCRTR2 (0.47) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16586032 | 0.81 | TDP1 (0.43) | L3MBTL1MAPK1KDM4EALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132463-A | Cardiovascular, skin, kidney, respiratory system, and gastrointestinal disorders | MERCK & CO., INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5047420-A | Platelet activating factor | MERCK & CO., INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0257921-A2 | New 1,3-diaryl cyclopentanes and derivatives thereof as paf antagonists | MERCK & CO. INC. (US) | 1988-03-02 | — | — | EP | disclosed |