Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500044 | 1.00 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL7166547 | 1.00 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL15804463 | 0.90 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL15762734 | 0.90 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL9719908 | 0.89 | L3MBTL1 (0.46) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL15804442 | 0.86 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1L3MBTL1 | |
| SCHEMBL20775229 | 0.86 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1PTGS2 | |
| SCHEMBL20775230 | 0.86 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1PTGS2 | |
| SCHEMBL24983762 | 0.86 | L3MBTL1 (0.50) | L3MBTL1MAPK1PTGS2KDM4EALDH1A1 | |
| SCHEMBL28776333 | 0.85 | HTT (0.46) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9573934-B2 | Methods and compositions for the synthesis of multimerizing agents | ARIAD PHARMACEUTICALS, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-9573934-B2 | Methods and compositions for the synthesis of multimerizing agents | ARIAD PHARMACEUTICALS, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20150148543-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-28 | — | — | US | disclosed |
| US-20150148543-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-28 | — | — | US | disclosed |
| US-9024028-B2 | Methods and compositions for the synthesis of multimerizing agents | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-9024028-B2 | Methods and compositions for the synthesis of multimerizing agents | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-9024028-B2 | Methods and compositions for the synthesis of multimerizing agents | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20140171649-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | ARIAD PHARMACEUTICALS, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171649-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | ARIAD PHARMACEUTICALS, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| WO-2012103279-A2 | METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS | ARIAD PHARMACEUTICALS, INCORPORATED (US) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012103279-A2 | METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS | ARIAD PHARMACEUTICALS, INCORPORATED (US) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171649-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | PIP5K1C, PIP4K2C, IPMK | AKR1C3 1231/4885AKR1C2 1537/4885AKR1C1 1752/4885 |
| US-20150148543-A1 | Methods and Compositions for the Synthesis of Multimerizing Agents | PARG, POLI, MCM6 | AKR1C3 3127/4885AKR1C2 3307/4885AKR1C1 3709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.