Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.64 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.64 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.61 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10544630 | 0.83 | CYSLTR1 (0.84) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL8001866 | 0.80 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL10547475 | 0.80 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL10547998 | 0.79 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL29587847 | 0.78 | CYSLTR1 (0.68) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL6583310 | 0.78 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL7715797 | 0.77 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL10547699 | 0.77 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL4159309 | 0.77 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 | |
| SCHEMBL10690965 | 0.77 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |