Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15231797 | 0.92 | KDM4E (0.62) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL28565701 | 0.92 | ABCG2 (0.69) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL30558216 | 0.91 | ABCG2 (0.59) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL21647139 | 0.91 | ABCG2 (0.61) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL29080561 | 0.91 | ABCG2 (0.59) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL8782475 | 0.91 | ALDH1A1 (0.68) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL30758496 | 0.88 | KDM4E (0.65) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL29137753 | 0.88 | KDM4E (0.65) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL29080542 | 0.87 | ABCG2 (0.58) | KDM4EGAAKCNA3KMT2AHSD17B10 | |
| SCHEMBL30558208 | 0.87 | ABCG2 (0.56) | KDM4EGAAKCNA3KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104311518-B | A kind of preparation method of 6-methyl scutellarin genin | 南京中医药大学 | 2016-07-13 | — | — | CN | disclosed |
| US-7875650-B2 | Baicalein analogs; enhances bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme; 6-Acetoxy-5,7-dihydroxyflavone | YALE UNIVERSITY (US) | 2011-01-25 | — | — | US | disclosed |
| CN-101768146-A | Method for preparing benzoyl-flavone | SUOPING XU | 2010-07-07 | — | — | CN | disclosed |
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | YALE UNIVERSITY (US) | 2007-07-12 | — | — | US | disclosed |
| WO-2005075449-A1 | COMPOUNDS AND METHODS TO INCREASE ANTI-P-GLYCOPROTEIN ACTIVITY OF BAICALEIN BY ALKYLATION ON THE A RING | YALE UNIVERSITY (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | ABCB1, ABCB11, ABCG2 | KDM4E 2696/4885GAA 1465/4885KCNA3 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.