Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68460 | 0.85 | NAALAD2 (0.52) | ACACBACACANAALAD2TDP1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7028451 | 0.83 | NAALAD2 (0.50) | ACACBACACANAALAD2TDP1CYP1A2 | |
| SCHEMBL6931571 | 0.83 | NAALAD2 (0.50) | ACACBACACANAALAD2TDP1CYP1A2 | |
| SCHEMBL6740712 | 0.83 | NAALAD2 (0.50) | ACACBACACANAALAD2TDP1CYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8839919 | 0.83 | NAALAD2 (0.50) | ACACBACACANAALAD2TDP1CYP1A2 | |
| SCHEMBL8582765 | 0.83 | NAALAD2 (0.50) | ACACBACACANAALAD2TDP1CYP1A2 | |
| Dimebutic Acid SCHEMBL6380229 | 0.81 | TDP1 (0.46) | ACACBACACATDP1ALDH1A1ACLY | |
| Water SCHEMBL4931332 | 0.81 | NAALAD2 (0.48) | ACACBACACANAALAD2TDP1CYP1A2 | |
| Succinic Acid SCHEMBL29364481 | 0.78 | TDP1 (0.59) | TDP1CYP1A2ALDH1A1GABRPGABRD | |
| Succinic Acid SCHEMBL1134610 | 0.78 | TDP1 (0.59) | TDP1CYP1A2ALDH1A1GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082883-A | Reduced viscosity polyblends of polyester and epoxy resins | EASTMAN KODAK COMPANY (US) | 1992-01-21 | — | — | US | disclosed |