Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TOP2A | P11388 | 4/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29442121 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL501238 | 0.89 | KDM4E (0.69) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL27976811 | 0.89 | KDM4E (0.59) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| Fluoride SCHEMBL5143436 | 0.87 | KDM4E (0.66) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL5143438 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL4299077 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10875970 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL2108243 | 0.85 | ALDH1A1 (0.64) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL10330778 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1TOP2ATOP2BLMNA | |
| SCHEMBL4145110 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1TOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5169853-A | Antibacterial agents; administering to mammals for infection | STERLING DRUG INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5075319-A | Bactericides | STERLING DRUG INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0417669-A2 | Pyridinyl-quinolone compounds, their preparation and use | STERLING WINTHROP INC. (US) | 1991-03-20 | — | — | EP | disclosed |