Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | TOP2A | P11388 | 4/20 | 0.64 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28459278 | 0.99 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL541544 | 0.99 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL541543 | 0.99 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| Oxalic Acid SCHEMBL27745929 | 0.96 | ALDH1A1 (0.60) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL4718738 | 0.95 | KDM4E (0.60) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL22506727 | 0.90 | ALDH1A1 (0.52) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL501238 | 0.89 | KDM4E (0.69) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL29442121 | 0.89 | KDM4E (0.69) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL9844577 | 0.89 | KDM4E (0.56) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL28750493 | 0.89 | ALDH1A1 (0.56) | ALDH1A1KDM4ETOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 417 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160224-B | Preparation method and application of rare earth co-doped complex | 江西师范大学 | 2024-08-06 | — | — | CN | claimed |
| CN-117362227-A | Synthesis method of quinolone carboxylic ester | 潍坊中农联合化工有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-109852377-B | Seven-core Ln-Ba cluster crystalline material and preparation method and application thereof | 江西师范大学 | 2023-03-21 | — | — | CN | claimed |
| US-11555016-B2 | Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2023-01-17 | — | — | US | claimed |
| CN-115246814-A | Synthetic method of fluoroquinolone antibacterial drugs | 江苏开元药业有限公司 | 2022-10-28 | — | — | CN | claimed |
| CN-115160224-A | Preparation method and application of novel rare earth co-doped complex | 江西师范大学 | 2022-10-11 | — | — | CN | claimed |
| US-20220235008-A1 | PLEUROMULIN 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID ESTER WITH ANTIBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME | SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2022-07-28 | — | — | US | claimed |
| CN-108659023-B | Rare earth-potassium bimetallic complex with extremely high fluorescence quantum yield | 江西师范大学 | 2021-10-01 | — | — | CN | claimed |
| CN-108976432-B | Alkali metal modified lanthanide coordination polymer and preparation method and application thereof | 江西师范大学 | 2021-09-07 | — | — | CN | claimed |
| CN-106008540-A | Heterocyclic aromatic acid ester type podophyllotoxin derivatives with anti-tumor activity as well as preparation method and application | 遵义医学院 | 2016-10-12 | — | — | CN | claimed |
| WO-2002085886-A2 | CHIRAL, BROAD-SPECTRUM ANTIBACTERIAL 7-SUBSTITUTED PIPERIDINO-QUINOLONE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS | WOCKHARDT LIMITED (IN) | 2002-10-31 | — | — | WO | claimed |
| WO-1997020849-A1 | CEPHALOSPORIN FLUOROQUINOLONATE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LABORATORIOS ARANDA, S.A. DE C.V. (IT) | 1997-06-12 | — | — | WO | claimed |
| EP-0274033-B1 | PROCESS FOR THE PREPARATION OF QUINOLINECARBOXYLIC ACIDS | BAYER AG (DE) | 1992-03-11 | — | — | EP | claimed |
| US-5095112-A | PROCESS FOR THE PREPARATION OF QUINOLONECARBOXYLIC ACID ESTERS | BAYER AKTIENGESELLSCHAFT (DE) | 1992-03-10 | — | — | US | claimed |
| EP-0274033-A1 | Process for the preparation of quinolinecarboxylic acids | BAYER AG (DE) | 1988-07-13 | — | — | EP | claimed |
| CN-87107230-A | Quinoline carboxylic acid's method for making | — | 1988-07-06 | — | — | CN | claimed |
| US-4620007-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1986-10-28 | — | — | US | claimed |
| EP-0078362-B1 | 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLINE-3-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1986-10-22 | — | — | EP | claimed |
| EP-0113093-B1 | 1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(ALKYL-1-PIPERAZINYL)-3-QUINOLINE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |
| EP-0078362-A2 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1983-05-11 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11555016-B2 | Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same | PLEC, MRPL21, MYADM | ALDH1A1 183/4885KDM4E 4296/4885TOP2A 658/4885 |
| US-20220235008-A1 | PLEUROMULIN 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID ESTER WITH ANTIBACTERIAL ACTIVITY AND A METHOD OF PREPARING THE SAME | PLEC, MRPL21, MYADM | ALDH1A1 183/4885KDM4E 4296/4885TOP2A 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.