Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | UNG | P13051 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8580569 | 0.85 | MAPT (0.44) | TDP1KDM4EMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL3033625 | 0.84 | MAPT (0.43) | TDP1KDM4EMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL25031282 | 0.82 | GSK3B (0.52) | TDP1TP53UNGPTGS2TTR | |
| SCHEMBL29838127 | 0.82 | ALDH1A1 (0.52) | TDP1TP53KDM4EUNGPTGS2 | |
| SCHEMBL25031506 | 0.82 | ALDH1A1 (0.52) | TDP1TP53KDM4EUNGPTGS2 | |
| SCHEMBL29838103 | 0.82 | GSK3B (0.52) | TDP1TP53UNGPTGS2TTR | |
| SCHEMBL4443836 | 0.81 | CYP2D6 (0.45) | TDP1TP53UNGPTGS2MEN1 | |
| SCHEMBL1720943 | 0.81 | MEN1 (0.59) | TDP1TP53KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL10389972 | 0.80 | SMN1; SMN2 (0.54) | TDP1MAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL14992845 | 0.80 | TDP1 (0.47) | TDP1TP53MAPTSMN1; SMN2UNG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |