Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.46 |
| ▸ | ESR1 | P03372 | 5/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29076111 | 0.80 | ERN1 (0.50) | ERN1ESR1ESR2HSD17B10PELI1 | |
| SCHEMBL9721301 | 0.80 | ERN1 (0.47) | ERN1CA12CA9 | |
| SCHEMBL28111651 | 0.79 | ERN1 (0.47) | ERN1ESR1ESR2HSD17B10PELI1 | |
| SCHEMBL9721232 | 0.76 | APP (0.46) | ERN1KDM4EMAPTRAB9A | |
| SCHEMBL8011498 | 0.76 | HSD17B10 (0.50) | ERN1ESR1ESR2HSD17B10PELI1 | |
| SCHEMBL31339466 | 0.75 | HPGD (0.46) | ERN1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL9721295 | 0.75 | HPGD (0.46) | ERN1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL6638877 | 0.74 | ERN1 (0.44) | ERN1ESR1ESR2PELI1ALDH5A1 | |
| SCHEMBL9721333 | 0.72 | ERN1 (0.42) | ERN1MAPTALDH1A1LMNA | |
| SCHEMBL9721276 | 0.71 | ESR1 (0.44) | ERN1ESR1ESR2CA12HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |