Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 15/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721275 | 0.87 | TLR8 (0.40) | ERN1MAPTALDH1A1 | |
| SCHEMBL9721232 | 0.79 | APP (0.46) | ERN1MAPTPTGS2 | |
| SCHEMBL5734028 | 0.76 | ERN1 (0.46) | ERN1MCL1MAPTALDH1A1LMNA | |
| SCHEMBL9721301 | 0.76 | ERN1 (0.47) | ERN1 | |
| SCHEMBL9721357 | 0.75 | TLR8 (0.37) | ERN1 | |
| SCHEMBL9721340 | 0.72 | ERN1 (0.46) | ERN1MAPTALDH1A1LMNA | |
| SCHEMBL9721255 | 0.72 | ERN1 (0.39) | ERN1MCL1MAPTALDH1A1LMNA | |
| SCHEMBL7142672 | 0.72 | ERN1 (0.41) | ERN1MCL1MAPTALDH1A1LMNA | |
| SCHEMBL5737950 | 0.71 | MCL1 (0.50) | ERN1MCL1ALDH1A1LMNA | |
| SCHEMBL14580133 | 0.71 | ALDH1A1 (0.43) | ERN1MCL1ALDH1A1LMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |