Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | ERN1 | O75460 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721275 | 0.85 | TLR8 (0.40) | ERN1KDM4EMAPT | |
| SCHEMBL9721333 | 0.79 | ERN1 (0.42) | ERN1PTGS2MAPT | |
| SCHEMBL9721340 | 0.76 | ERN1 (0.46) | ERN1KDM4ERAB9AMAPT | |
| SCHEMBL21484877 | 0.75 | APP (0.64) | APPERN1KDM4EPTGS2RAB9A | |
| SCHEMBL6638868 | 0.74 | ERN1 (0.67) | APPERN1 | |
| SCHEMBL9721301 | 0.73 | ERN1 (0.47) | ERN1 | |
| SCHEMBL31339466 | 0.71 | HPGD (0.46) | ERN1KDM4EMAPT | |
| SCHEMBL9721295 | 0.71 | HPGD (0.46) | ERN1KDM4EMAPT | |
| SCHEMBL9721278 | 0.71 | KDM4E (0.40) | ERN1KDM4EMAPT | |
| SCHEMBL9721268 | 0.71 | NOX4 (0.42) | APPERN1KDM4EPTGS2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |