Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.71 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 7/20 | 0.52 |
| ▸ | PPARA | Q07869 | 7/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721956 | 0.89 | KDR (0.57) | KDRFFAR1KDM1AMAPTPPARG | |
| SCHEMBL5802990 | 0.86 | KDR (0.72) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL3528719 | 0.86 | KDR (0.76) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL10372016 | 0.86 | FFAR1 (0.65) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL4743991 | 0.85 | KDR (0.71) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6160505 | 0.84 | KDR (0.77) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6248263 | 0.84 | KDR (0.63) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL4033640 | 0.83 | KDR (0.79) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL4034790 | 0.83 | KDR (1.00) | KDRFFAR1MAPTPPARGPPARA | |
| SCHEMBL6157414 | 0.82 | KDR (0.67) | KDRFFAR1MAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310370-A1 | 2-aryl substituted heterocyclic compounds as antiallgeric and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-05 | — | — | EP | claimed |
| US-5103014-A | Antiinflammatory or/and antiallergic agent | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| US-4942236-A | ANTIASTHMATICS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-07-17 | — | — | US | disclosed |
| US-4895953-A | 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-01-23 | — | — | US | disclosed |
| US-4826990-A | LIPOXYGENASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0310370-A1 | 2-aryl substituted heterocyclic compounds as antiallgeric and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |