Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | TRPV2 | Q9Y5S1 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15257370 | 0.76 | RXRA (0.38) | ALDH1A1 | |
| SCHEMBL1760537 | 0.70 | HMGCR (0.64) | HMGCRESR1ESR2CNR1CNR2 | |
| SCHEMBL8013800 | 0.69 | RXRA (0.51) | HMGCRHSD17B1CYP1A2 | |
| SCHEMBL15867102 | 0.69 | TYR (0.40) | TRPA1CNR1CNR2TRPV1TRPV3 | |
| SCHEMBL1276072 | 0.68 | CYP3A4 (0.49) | HMGCRLMNAMAPTALDH1A1HTT | |
| SCHEMBL11024762 | 0.68 | HMGCR (0.61) | HMGCRESR1ESR2CNR1CNR2 | |
| SCHEMBL11840310 | 0.66 | HMGCR (0.59) | HMGCRESR1ESR2CNR1CNR2 | |
| SCHEMBL4460505 | 0.66 | HMGCR (0.42) | HMGCRESR1ESR2ALOX5LMNA | |
| SCHEMBL9722365 | 0.65 | TP53 (0.33) | ESR1ESR2TRPA1CNR1CNR2 | |
| SCHEMBL10459570 | 0.62 | HMGCR (0.42) | HMGCRLMNAMAPTALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |