Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 5/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10631588 | 0.87 | KMT2A (0.38) | MRGPRX1IKBKBKMT2ACES2CES1 | |
| SCHEMBL5907935 | 0.84 | ACKR3 (0.37) | MRGPRX1IKBKBKMT2ACES2CES1 | |
| SCHEMBL27731731 | 0.81 | HSP90AB1 (0.43) | MRGPRX1IKBKBKMT2ACES2CES1 | |
| SCHEMBL9722967 | 0.80 | ALDH1A1 (0.42) | IKBKBCES2CES1MAPTSMN1; SMN2 | |
| SCHEMBL9722911 | 0.77 | IKBKB (0.38) | MRGPRX1IKBKBKMT2ACES2CES1 | |
| SCHEMBL9722931 | 0.75 | CES2 (0.44) | IKBKBCES2CES1CLCN2HDAC1 | |
| SCHEMBL3810854 | 0.75 | CLCN2 (0.52) | IKBKBKMT2ACES2CES1MAPT | |
| SCHEMBL6535624 | 0.75 | IKBKB (0.36) | IKBKBCES2CES1MAPTSMN1; SMN2 | |
| SCHEMBL10481312 | 0.75 | ALDH1A1 (0.38) | MRGPRX1IKBKBKMT2ACES2CES1 | |
| SCHEMBL14627554 | 0.74 | FFAR4 (0.36) | IKBKBKMT2ACES2CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079264-A | CHEMICAL PROCESS | THE BOOTS CO. PLC (GB) | 1992-01-07 | — | — | US | disclosed |
| EP-0317149-B1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | The Boots Company PLC (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5011931-A | For treatment of cardiovascular disorders; hypotensive agents | THE BOOTS COMPANY PLC (GB) | 1991-04-30 | — | — | US | disclosed |
| EP-0343206-A1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | The Boots Company PLC (GB) | 1989-11-29 | — | — | EP | disclosed |
| WO-1989004827-A1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | THE BOOTS COMPANY PLC (GB) | 1989-06-01 | — | — | WO | disclosed |
| EP-0317149-A1 | Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments | The Boots Company PLC (GB) | 1989-05-24 | — | — | EP | disclosed |