Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722927 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9722955 | 0.78 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9722968 | 0.75 | MEN1 (0.38) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL10953312 | 0.74 | KDM4E (0.50) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9796480 | 0.71 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9722911 | 0.69 | IKBKB (0.38) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL28131348 | 0.68 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL10556328 | 0.67 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2KMT2AKDM4ELMNA | |
| SCHEMBL19089279 | 0.67 | NPC1 (0.52) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL14382356 | 0.67 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079264-A | CHEMICAL PROCESS | THE BOOTS CO. PLC (GB) | 1992-01-07 | — | — | US | disclosed |
| EP-0317149-B1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | The Boots Company PLC (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5011931-A | For treatment of cardiovascular disorders; hypotensive agents | THE BOOTS COMPANY PLC (GB) | 1991-04-30 | — | — | US | disclosed |
| EP-0343206-A1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | The Boots Company PLC (GB) | 1989-11-29 | — | — | EP | disclosed |
| EP-0317149-A1 | Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments | The Boots Company PLC (GB) | 1989-05-24 | — | — | EP | disclosed |