Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9722953 | 0.81 | MEN1 (0.39) | MEN1KMT2AHSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL9722938 | 0.81 | MEN1 (0.36) | MEN1KMT2AHSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL9722965 | 0.77 | MEN1 (0.37) | MEN1KMT2AHSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL9722964 | 0.75 | ALDH1A1 (0.46) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9796430 | 0.73 | HPGDS (0.42) | KMT2ALMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL9796608 | 0.73 | MAPT (0.36) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9796468 | 0.70 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL9817692 | 0.70 | ALDH1A1 (0.40) | MEN1KMT2AHSP90AA1SMN1; SMN2MAPT | |
| SCHEMBL9796262 | 0.69 | HTT (0.51) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9722918 | 0.69 | HMGCR (0.36) | MEN1KMT2ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079264-A | CHEMICAL PROCESS | THE BOOTS CO. PLC (GB) | 1992-01-07 | — | — | US | disclosed |
| US-5011931-A | For treatment of cardiovascular disorders; hypotensive agents | THE BOOTS COMPANY PLC (GB) | 1991-04-30 | — | — | US | disclosed |
| WO-1989004827-A1 | PROCESS FOR THE SYNTHESIS OF 3-THIO-4-QUINOLONE DERIVATIVES AND INTERMEDIATE COMPOUNDS FOR USE THEREIN, AND THEIR USE AS MEDICAMENTS | THE BOOTS COMPANY PLC (GB) | 1989-06-01 | — | — | WO | disclosed |