Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9290882 | 0.98 | LMNA (0.63) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL9861586 | 0.97 | LMNA (0.65) | LMNAKDM4EHPGDDUSP3GAA | |
| Bromide SCHEMBL9290816 | 0.89 | CA12 (0.51) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL9505845 | 0.87 | CA12 (0.53) | LMNAKDM4EHPGDDUSP3GAA | |
| Bromide SCHEMBL9290773 | 0.87 | LMNA (0.46) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL9505830 | 0.85 | LMNA (0.47) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL2905467 | 0.82 | KDM4E (0.45) | LMNAKDM4EHPGDDUSP3GAA | |
| Bromide SCHEMBL9291049 | 0.81 | KDM4E (0.42) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL14595368 | 0.81 | HPGD (0.60) | LMNAKDM4EHPGDDUSP3GAA | |
| SCHEMBL6206098 | 0.80 | GAA (0.66) | LMNAKDM4EHPGDDUSP3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140048-A | Inhibitors of nonenzymatic cross-linking | THE ROCKEFELLER UNIVERSITY (US) | 1992-08-18 | — | — | US | disclosed |