Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HMGCR | P04035 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1849754 | 0.80 | TSHR (0.40) | TSHRHMGCRTDP1TP53POLB | |
| SCHEMBL10384698 | 0.79 | TSHR (0.36) | TSHRTDP1TP53POLBALDH1A1 | |
| SCHEMBL4117495 | 0.75 | POLB (0.38) | TSHRPOLBALDH1A1LMNAMAPT | |
| SCHEMBL9652021 | 0.74 | TSHR (0.48) | TSHRHMGCRTDP1TP53POLB | |
| SCHEMBL8617347 | 0.74 | PPARD (0.36) | TSHRHMGCRTDP1TP53POLB | |
| SCHEMBL8670808 | 0.72 | HMGCR (0.37) | TSHRHMGCRTDP1ALDH1A1LMNA | |
| SCHEMBL3772237 | 0.71 | TSHR (0.42) | TSHRTDP1TP53POLBALDH1A1 | |
| SCHEMBL19468552 | 0.70 | TSHR (0.43) | TSHRHMGCRTDP1TP53POLB | |
| SCHEMBL7644740 | 0.70 | TSHR (0.43) | TSHRHMGCRTDP1TP53POLB | |
| SCHEMBL9063886 | 0.70 | PPARD (0.44) | TSHRHMGCRTDP1TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | disclosed |
| US-4877603-A | ANTICALCULUS AND ANTIPLAQUE COMPOSITION CONTAINING A GEMINAL DIPHOSPHONATE POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 1989-10-31 | — | — | US | disclosed |
| EP-0321233-A1 | Oral compositions | THE PROCTER & GAMBLE COMPANY (US) | 1989-06-21 | — | — | EP | disclosed |