Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848345 | 0.84 | LMNA (0.53) | LMNACYP1A2KDM4EHPGDHSD17B10 | |
| SCHEMBL6250314 | 0.81 | KDM4E (0.64) | LMNACYP1A2L3MBTL1KDM4EHPGD | |
| SCHEMBL9724298 | 0.80 | MAPT (0.40) | LMNACYP1A2L3MBTL1KDM4EHPGD | |
| SCHEMBL3531515 | 0.78 | LMNA (0.66) | LMNACYP1A2L3MBTL1KDM4EELANE | |
| SCHEMBL6846717 | 0.77 | KMT2A (0.52) | LMNAL3MBTL1HTTHPGDMAPT | |
| SCHEMBL30572382 | 0.74 | LMNA (1.00) | LMNACYP1A2L3MBTL1KDM4EELANE | |
| SCHEMBL3760247 | 0.74 | LMNA (0.61) | LMNACYP1A2L3MBTL1KDM4EELANE | |
| SCHEMBL29523105 | 0.74 | LMNA (0.61) | LMNACYP1A2L3MBTL1KDM4EELANE | |
| SCHEMBL438604 | 0.74 | NCF1 (0.63) | LMNACYP1A2L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL6766825 | 0.74 | LMNA (0.61) | LMNACYP1A2L3MBTL1KDM4EELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |