Pyrophosphoric Acid

Pyrophosphoric Acid

SCHEMBL9724291

O=C(O)CI.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.56

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 3/20 0.56
TDP1 Q9NUW8 3/20 0.56
FDPS P14324 1/20 0.56
MVD P53602 4/20 0.39
LMNA P02545 2/20 0.39
HPGD P15428 2/20 0.39
MEN1 O00255 1/20 0.39
TSHR P16473 1/20 0.39
KMT2A Q03164 1/20 0.39
PGK1 P00558 1/20 0.34
PGK2 P07205 1/20 0.34
PEPD P12955 1/20 0.33
PGD P52209 1/20 0.32
CA4 P22748 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GMNN O75496 1/20 0.32
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrophosphoric Acid SCHEMBL4957040 0.80 BLM (0.59) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL29080962 0.80 BLM (0.59) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL4016977 0.78 BLM (0.77) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL1680134 0.78 FDPS (0.91) BLMTDP1FDPSMVDPEPD
Pyrophosphoric Acid SCHEMBL18170266 0.78 BLM (0.56) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL8405467 0.76 BLM (0.71) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL8060467 0.76 BLM (0.71) BLMTDP1FDPSMVDLMNA
Pyrophosphoric Acid SCHEMBL8811725 0.75 FDPS (0.83) BLMTDP1FDPSMVDPEPD
Pyrophosphoric Acid SCHEMBL4420910 0.75 FDPS (0.83) BLMTDP1FDPSMVDPEPD
Pyrophosphoric Acid SCHEMBL27618497 0.75 FDPS (0.83) BLMTDP1FDPSMVDPEPD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5165927-A Cysteine modified to reduce ADP-ribosyl transferase activity UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1992-11-24 US disclosed
US-5032398-A Polyphosphate, sulfhydryl reductant, detergent NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 1991-07-16 US disclosed