Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431819 | 0.85 | MAPT (0.46) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL19554458 | 0.85 | GPR35 (0.39) | LMNAMAPTL3MBTL1GPR35PTGES | |
| SCHEMBL17502194 | 0.82 | LMNA (0.52) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL30075028 | 0.81 | MAPT (0.44) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL28639349 | 0.81 | MAPT (0.44) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL17539136 | 0.79 | LMNA (0.49) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL3051550 | 0.78 | MAPT (0.60) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL9724286 | 0.76 | MAPT (0.40) | LMNAMAPTL3MBTL1CRHR1NR4A2 | |
| SCHEMBL20680298 | 0.76 | CD38 (0.53) | LMNAPOLB | |
| SCHEMBL17539137 | 0.76 | MAPT (0.45) | LMNAMAPTL3MBTL1CRHR1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |