Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10357861 | 1.00 | TSHR (0.39) | TSHRCHRNB2CHRNA4RECQLPOLB | |
| SCHEMBL9724931 | 0.70 | TSHR (0.45) | TSHRRECQLCYP19A1ALDH1A1HPGD | |
| Bromide SCHEMBL3923746 | 0.69 | TSHR (0.44) | TSHRRECQLCYP19A1ALDH1A1HPGD | |
| SCHEMBL164239 | 0.62 | TSHR (0.59) | TSHRRECQLPOLBALDH1A1HPGD | |
| SCHEMBL4352982 | 0.62 | TSHR (0.51) | TSHRRECQLPOLBALDH1A1HPGD | |
| SCHEMBL9343574 | 0.61 | ALDH1A1 (0.47) | TSHRCHRNB2CHRNA4ALDH1A1KDM4E | |
| SCHEMBL9343576 | 0.61 | ALDH1A1 (0.47) | TSHRCHRNB2CHRNA4ALDH1A1KDM4E | |
| SCHEMBL25003079 | 0.61 | MEN1 (0.66) | TSHRALDH1A1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL9818810 | 0.61 | MEN1 (0.66) | TSHRALDH1A1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL9818814 | 0.61 | MEN1 (0.66) | TSHRALDH1A1TDP1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229501-B1 | THIADIAZOLE ANTIVIRAL AGENTS | ELI LILLY AND COMPANY (US) | 1990-12-27 | — | — | EP | claimed |
| EP-0229501-A1 | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | claimed |
| US-5093324-A | Ribose-substituted | ELI LILLY AND COMPANY (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0229501-B1 | THIADIAZOLE ANTIVIRAL AGENTS | ELI LILLY AND COMPANY (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0392769-A1 | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4835168-A | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0229501-A1 | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |