Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724931 | 0.98 | TSHR (0.45) | TSHRRECQLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6360177 | 0.80 | ALDH1A1 (0.53) | RECQLALDH1A1ALOX15HSD17B10LMNA | |
| SCHEMBL10357861 | 0.69 | TSHR (0.39) | TSHRRECQLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9724804 | 0.69 | TSHR (0.39) | TSHRRECQLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4361625 | 0.66 | P2RX7 (0.56) | TSHRRECQLSMN1; SMN2NPC1RAB9A | |
| SCHEMBL23749756 | 0.64 | SMN1; SMN2 (0.47) | TSHRSMN1; SMN2NPC1RAB9ACYP19A1 | |
| SCHEMBL4365345 | 0.64 | TSHR (0.56) | TSHRRECQLCYP19A1ALDH1A1KDM4E | |
| SCHEMBL144813 | 0.63 | TSHR (0.69) | TSHRRECQLSMN1; SMN2CYP19A1ALDH1A1 | |
| SCHEMBL23749741 | 0.63 | CHRNB2 (0.59) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7174067 | 0.62 | RECQL (0.56) | TSHRRECQLCYP19A1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560456-B2 | Pesticidal pyridinecarboxamide derivatives | MERIAL LIMITED (US) | 2009-07-14 | — | — | US | disclosed |
| EP-1507762-B1 | PESTICIDAL PYRIDINECARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE GMBH (DE) | 2006-08-02 | — | — | EP | disclosed |
| US-20050227970-A1 | Pesticidal pyridinecarboxamide derivatives | MERIAL LIMITED | 2005-10-13 | — | — | US | disclosed |
| EP-1507762-A1 | PESTICIDAL PYRIDINECARBOXAMIDE DERIVATIVES | Bayer CropScience GmbH (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097605-A1 | PESTICIDAL PYRIDINECARBOXAMIDE DERIVATIVES | BAYER CROPSCIENCE GMBH (DE) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227970-A1 | Pesticidal pyridinecarboxamide derivatives | DDT, ACHE, PTMS | TSHR 1529/4885RECQL 1556/4885SMN1; SMN2 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.