Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | AQP4 | P55087 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14096368 | 0.82 | MIF (0.62) | MIFTAAR1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL20603903 | 0.81 | — | — | |
| SCHEMBL3989080 | 0.72 | — | — | |
| SCHEMBL10357728 | 0.70 | ALDH1A1 (0.46) | MIFTAAR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL2872394 | 0.69 | POLB (0.58) | TAAR1ALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL19974322 | 0.69 | NPC1 (0.58) | MIFTAAR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL19974323 | 0.69 | NPC1 (0.58) | MIFTAAR1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8356392 | 0.68 | POLB (0.56) | TAAR1ALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL1970389 | 0.68 | POLB (0.56) | TAAR1ALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL12649504 | 0.68 | POLB (0.60) | TAAR1ALDH1A1HPGDHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093324-A | Ribose-substituted | ELI LILLY AND COMPANY (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0229501-B1 | THIADIAZOLE ANTIVIRAL AGENTS | ELI LILLY AND COMPANY (US) | 1990-12-27 | — | — | EP | disclosed |
| EP-0392769-A1 | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4835168-A | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0229501-A1 | Thiadiazole antiviral agents | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |