Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7642996 | 0.83 | QPCT (0.56) | SOD1LMNAALDH1A1POLBCYP19A1 | |
| SCHEMBL8288918 | 0.77 | LMNA (0.64) | LMNANPC1MAPTRAB9APKM | |
| SCHEMBL6657973 | 0.77 | LMNA (0.68) | LMNANPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL11717638 | 0.76 | LMNA (0.61) | LMNANPC1MAPTRAB9APKM | |
| SCHEMBL5189230 | 0.76 | QPCT (0.69) | SOD1NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL8596871 | 0.76 | LMNA (0.67) | LMNANPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL9849551 | 0.76 | ALDH1A1 (0.60) | SOD1LMNANPC1RAB9AALDH1A1 | |
| SCHEMBL20945467 | 0.75 | MAPT (0.67) | LMNANPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL5189414 | 0.75 | CYP19A1 (0.60) | LMNANPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL4280470 | 0.75 | KAT2B (0.51) | SOD1LMNANPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4217958-A | — | — | None | — | — | JP | disclosed |
| JP-H04217958-A | PYRIDINE DEREVATIVE AND RELATING AZAHETEROCYCLE DERIVATIVE AS CARDIAC VASCULAR DRUG | AMERICAN CYANAMID CO | 1992-08-07 | — | — | JP | disclosed |
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |