Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 9/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600052 | 0.89 | THRB (0.56) | THRBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL16554939 | 0.82 | THRB (0.42) | THRBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL2953498 | 0.80 | ALDH1A1 (0.50) | THRBKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL1667181 | 0.79 | THRB (0.52) | THRBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL31676719 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL3456805 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL466296 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL2174138 | 0.78 | KDM4E (0.50) | THRBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6999515 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL3502815 | 0.78 | THRB (0.46) | THRBKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0142241-A1 | Dihydroxybenzamide derivatives having anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-05-22 | — | — | EP | claimed |
| US-5140020-A | Antiinflammatory agents | KUREHA KAGATU KOGYO KABUSHIKI KAISHA (JP) | 1992-08-18 | — | — | US | disclosed |
| US-4725598-A | Derivative of dihydroxybenzamide and a pharmaceutical composition having an anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0142241-B1 | DIHYDROXYBENZAMIDE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-12-02 | — | — | EP | disclosed |
| EP-0142241-A1 | Dihydroxybenzamide derivatives having anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-05-22 | — | — | EP | disclosed |