Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9619537 | 0.92 | LMNA (0.49) | NPC1RAB9ALMNAMAPK14XDH | |
| SCHEMBL9619551 | 0.90 | LMNA (0.50) | RAB9ALMNAXDHCTSSKMO | |
| SCHEMBL9848084 | 0.79 | CFTR (0.49) | LMNAMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL5593071 | 0.76 | LMNA (0.56) | LMNAXDHCTSSKMOCTSK | |
| SCHEMBL3881826 | 0.76 | KIF11 (0.67) | NPC1RAB9AMAPK14MAPK13RAF1 | |
| SCHEMBL9874814 | 0.75 | NPC1 (0.55) | NPC1RAB9AMAPK14MAPK13RAF1 | |
| SCHEMBL3874359 | 0.74 | LMNA (0.54) | LMNAMAPK14XDHCTSSKMO | |
| SCHEMBL6468978 | 0.73 | MAPK14 (0.70) | MAPK14MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL11467792 | 0.72 | LMNA (0.58) | LMNAMAPK14XDHCTSSKMO | |
| SCHEMBL17014793 | 0.72 | KDM4E (0.69) | NPC1RAB9ALMNAADAM17KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4234849-A | — | — | None | — | — | JP | disclosed |
| JP-H04234849-A | 2-ARYL-6-HETARYL PYRIDINE DERIVATIVES | BAYER AG | 1992-08-24 | — | — | JP | disclosed |
| EP-0451585-A2 | 2-aryl-6-hetarylpyridine derivatives | BAYER AG (DE) | 1991-10-16 | — | — | EP | disclosed |