⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30197806 | 0.82 | L3MBTL1 (0.40) | — | |
| SCHEMBL5202776 | 0.80 | — | — | |
| SCHEMBL14302183 | 0.79 | MAPT (0.36) | — | |
| SCHEMBL9285625 | 0.78 | — | — | |
| SCHEMBL22019922 | 0.78 | — | — | |
| SCHEMBL446876 | 0.78 | — | — | |
| SCHEMBL13262611 | 0.78 | — | — | |
| SCHEMBL13589000 | 0.78 | — | — | |
| SCHEMBL11398624 | 0.78 | MAPT (0.37) | — | |
| Hydrochloric Acid SCHEMBL5149348 | 0.77 | MAPT (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107827880-B | Carbonitrile compound containing imidazole and 1,3, 4-oxadiazole structure and preparation method and application thereof | 浙江工业大学上虞研究院有限公司 | 2020-05-22 | — | — | CN | claimed |
| CN-107827880-A | A kind of first nitrile compounds containing imidazoles and 1,3,4 oxadiazole structures and its preparation method and application | 浙江工业大学上虞研究院有限公司 | 2018-03-23 | — | — | CN | claimed |
| EP-4382101-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | Eurofarma Laboratórios S.A. (BR) | 2024-06-12 | — | — | EP | disclosed |
| CN-117567690-A | temperature/pH dual-response chitosan/acidic polysaccharide hydrogel and preparation method and application thereof | 大连市第二十四中学 | 2024-02-20 | — | — | CN | disclosed |
| EP-3885131-A1 | OPTICAL LAMINATE | LG CHEM, LTD. (KR) | 2021-09-29 | — | — | EP | disclosed |
| CN-107827880-B | Carbonitrile compound containing imidazole and 1,3, 4-oxadiazole structure and preparation method and application thereof | 浙江工业大学上虞研究院有限公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-107827880-A | A kind of first nitrile compounds containing imidazoles and 1,3,4 oxadiazole structures and its preparation method and application | 浙江工业大学上虞研究院有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-107406436-A | Oxinane yl-benzamide derivatives | 伊莱利利公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-102906093-B | NK-3 receptor selective antagonists compound, pharmaceutical composition and the using method in the receptor-mediated disease of NK-3 | EUROSCREEN S.A. (BE) | 2016-01-13 | — | — | CN | disclosed |
| EP-2650287-B9 | Thiazole Derivative and use thereof as VAP-1 Inhibitor | R TECH UENO LTD (JP) | 2015-08-05 | — | — | EP | disclosed |
| EP-2639229-B9 | Thiazole Derivative and use thereof as VAP-1 Inhibitor | R TECH UENO LTD (JP) | 2015-08-05 | — | — | EP | disclosed |
| EP-2650287-A1 | Thiazole Derivative and use thereof as VAP-1 Inhibitor | R-Tech Ueno, Ltd. (JP) | 2013-10-16 | — | — | EP | disclosed |
| EP-2639229-A2 | Thiazole Derivative and use thereof as VAP-1 Inhibitor | R-Tech Ueno, Ltd. (JP) | 2013-09-18 | — | — | EP | disclosed |
| US-8507690-B2 | Thiazole derivative and use thereof as VAP-1 inhibitor | R-TECH UENO, LTD. (JP) | 2013-08-13 | — | — | US | disclosed |
| CN-102906093-A | Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders | EUROSCREEN SA | 2013-01-30 | — | — | CN | disclosed |
| US-20110015240-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| CN-101932568-A | Thiazole derivative and use thereof as vap-1 inhibitor | R TECH UENO LTD | 2010-12-29 | — | — | CN | disclosed |
| EP-2252604-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-Tech Ueno, Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009096609-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2009-08-06 | — | — | WO | disclosed |
| WO-2001027087-A2 | PROCESS FOR MAKING BOC-PROTECTED 3-AMINOHYDANTOINS/THIOHYDANTOINS AND 3-AMINODIHYDROURACILS/DIHYDROTHIOURACILS | THE PROCTER & GAMBLE COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |