Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10168172 | 0.78 | MAPT (0.59) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL11188527 | 0.77 | ATM (0.56) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL23308373 | 0.77 | HCRTR1 (0.49) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL3875165 | 0.75 | GPR3 (0.58) | HTTMAPTALDH1A1HSD17B10KDM4E | |
| Adosopine SCHEMBL2109279 | 0.74 | MAPT (0.50) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL21564036 | 0.73 | HTT (0.61) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL346785 | 0.73 | GPR3 (0.65) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL31276757 | 0.73 | GPR3 (0.65) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL53107 | 0.72 | GPR3 (0.71) | HTTMAPTALDH1A1CYP2C19HSD17B10 | |
| SCHEMBL21312375 | 0.72 | GPR3 (0.71) | HTTMAPTALDH1A1CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | claimed |
| EP-0408525-A2 | Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1991-01-16 | — | — | EP | claimed |
| EP-0089322-B1 | TRICYCLIC DERIVATIVES OF 5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPIN-6-ONE HAVING PHARMACOLOGICAL AVTIVITY, AND METHOD FOR THEIR PREPARATION | A. Menarini S.a.S. (IT) | 1987-06-16 | — | — | EP | claimed |
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | disclosed |