Adosopine

Adosopine

SCHEMBL2109279

CC(=O)Nc1cccc2c(=O)n(C)c3ccccc3c(=O)c12

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
HTT P42858 2/20 0.50
KDM4E B2RXH2 6/20 0.49
KMT2A Q03164 5/20 0.49
ALDH1A1 P00352 5/20 0.49
USP2 O75604 3/20 0.49
HPGD P15428 2/20 0.49
HSD17B10 Q99714 2/20 0.49
MEN1 O00255 3/20 0.49
CYP2C19 P33261 2/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
MAPK1 P28482 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
TDP1 Q9NUW8 1/20 0.44
ERCC1 P07992 1/20 0.44
FEN1 P39748 1/20 0.44
ERCC4 Q92889 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10812522 0.86 RXFP1 (0.52) MAPTHTTKDM4EALDH1A1USP2
SCHEMBL9725671 0.74 HTT (0.54) MAPTHTTKDM4EKMT2AALDH1A1
SCHEMBL3781796 0.72 ALDH1A1 (0.57) MAPTHTTKDM4EKMT2AALDH1A1
SCHEMBL9725648 0.72 KDM4E (0.56) MAPTKDM4EKMT2AALDH1A1HPGD
SCHEMBL11188527 0.70 ATM (0.56) MAPTHTTKDM4EKMT2AALDH1A1
SCHEMBL383913 0.69 HTT (0.56) MAPTHTTKDM4EKMT2AALDH1A1
SCHEMBL9025257 0.69 KDM4E (0.40) MAPTKDM4EKMT2AALDH1A1USP2
SCHEMBL6581984 0.69 ALDH1A1 (0.42) MAPTKDM4EKMT2AALDH1A1USP2
SCHEMBL1900214 0.68 RXFP1 (0.66) MAPTKDM4EKMT2AALDH1A1HPGD
SCHEMBL8332038 0.67 KDM4E (0.63) MAPTKDM4EKMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-5080905-A THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) 1992-01-14 US claimed
EP-0408525-A2 Use in therapy of 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione and derivatives as drugs for use in the treatment of urinary incontinence A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1991-01-16 EP claimed
EP-0089322-B1 TRICYCLIC DERIVATIVES OF 5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPIN-6-ONE HAVING PHARMACOLOGICAL AVTIVITY, AND METHOD FOR THEIR PREPARATION A. Menarini S.a.S. (IT) 1987-06-16 EP claimed
US-4551451-A Tricyclic derivatives of 5,6-dihydro-11H-dibenzo (b,e) azepin-6-one having pharmacological activity A. MENARINI S.A.S. (IT) 1985-11-05 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9533056-B2 Dipeptide-based prodrug linkers for aliphatic amine-containing drugs ASCENDIS PHARMA AS (DK) 2017-01-03 US disclosed
EP-2525830-B1 DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS ASCENDIS PHARMA AS (DK) 2016-05-11 EP disclosed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP disclosed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO disclosed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US disclosed
US-5080905-A THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) 1992-01-14 US disclosed
EP-0089322-B1 TRICYCLIC DERIVATIVES OF 5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPIN-6-ONE HAVING PHARMACOLOGICAL AVTIVITY, AND METHOD FOR THEIR PREPARATION A. Menarini S.a.S. (IT) 1987-06-16 EP disclosed