Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725819 | 1.00 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7270342 | 0.86 | CA1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7270348 | 0.86 | CA1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7270337 | 0.86 | CA1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7297285 | 0.75 | ALDH1A1 (0.42) | KMT2AKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL7268440 | 0.74 | REN (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7268437 | 0.74 | REN (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7268445 | 0.74 | REN (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9146005 | 0.70 | CA1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL26838028 | 0.69 | CA1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106835-A | Hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-21 | — | — | US | disclosed |