Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255286 | 0.98 | GRIN2B (0.53) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| SCHEMBL29434614 | 0.98 | GRIN2B (0.53) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| Bicarbonate SCHEMBL2441660 | 0.96 | GRIN2B (0.51) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| Hydrochloric Acid SCHEMBL10493696 | 0.96 | GRIN2B (0.51) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| Glycine SCHEMBL2438253 | 0.91 | GRIN2B (0.47) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| SCHEMBL1742836 | 0.86 | GRIN2B (0.62) | GRIN2BSIGMAR1DPP4PRMT5MTNR1A | |
| SCHEMBL13846495 | 0.82 | GRIN2B (0.55) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| SCHEMBL13981017 | 0.81 | MTNR1A (0.51) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| SCHEMBL29378921 | 0.81 | KDM1A (0.50) | GRIN2BSIGMAR1DPP4MAPTPRMT5 | |
| SCHEMBL399565 | 0.81 | KDM1A (0.50) | GRIN2BSIGMAR1DPP4MAPTPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098892-A | Angiotensin converting enzyme inhibitors as hypotensive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-24 | — | — | US | disclosed |