SCHEMBL9726414

SCHEMBL9726414

CCOC(=O)C(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnnn1C(C)C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.40
MAPT P10636 4/20 0.39
KMT2A Q03164 3/20 0.39
LMNA P02545 3/20 0.39
MEN1 O00255 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
SLC5A1 P13866 1/20 0.38
SLC5A2 P31639 1/20 0.38
KDM4E B2RXH2 3/20 0.37
GAA P10253 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 3/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
CASP3 P42574 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9726429 0.86 HMGCR (0.48) HMGCRMAPTKMT2ALMNAMEN1
SCHEMBL9726594 0.85 KDM4E (0.40) HMGCRMAPTKMT2ALMNAMEN1
SCHEMBL9726610 0.83 HMGCR (0.39) HMGCRCYP1A2CYP2C9CYP2C19ALDH1A1
SCHEMBL9726520 0.78 ADORA2A (0.39) MAPTKMT2ALMNAMEN1CYP1A2
SCHEMBL9726502 0.78 HSD17B10 (0.43) HMGCRMAPTKMT2ALMNAMEN1
SCHEMBL9726484 0.75 HMGCR (0.43) HMGCRHPGDTSHR
SCHEMBL9726819 0.75 MAPT (0.41) MAPTKMT2ALMNAMEN1CYP1A2
SCHEMBL9726517 0.75 HMGCR (0.51) HMGCRKDM4EHPGDHSD17B10
SCHEMBL9726770 0.75 HMGCR (0.51) HMGCRKDM4EHPGDHSD17B10
SCHEMBL9726604 0.74 HMGCR (0.62) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5110940-A Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase BRISTOL-MYERS COMPANY (US) 1992-05-05 US disclosed
US-5068346-A Anticholesterol agents BRISTOL-MYERS COMPANY (US) 1991-11-26 US disclosed
US-4897490-A DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE BRISTOL-MEYERS COMPANY (US) 1990-01-30 US disclosed
WO-1988006584-A1 ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS BRISTOL-MYERS COMPANY (US) 1988-09-07 WO disclosed