SCHEMBL9726610

SCHEMBL9726610

CC(C)n1nnnc1C(C(=O)O)=C(c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 2/20 0.39
HPGD P15428 2/20 0.38
HCAR3 P49019 1/20 0.38
HCAR2 Q8TDS4 1/20 0.38
HSD11B1 P28845 1/20 0.36
ALDH1A1 P00352 2/20 0.35
TSHR P16473 2/20 0.35
NPC1 O15118 3/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
RAB9A P51151 1/20 0.34
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9726661 0.83 HMGCR (0.47) HMGCRHPGDHSD11B1ALDH1A1RAB9A
SCHEMBL9726414 0.83 HMGCR (0.40) HMGCRHPGDALDH1A1TSHRNPC1
SCHEMBL9726484 0.78 HMGCR (0.43) HMGCRHPGDHCAR3HCAR2TSHR
SCHEMBL10610685 0.77 CES2 (0.41) HMGCRHPGDHCAR3HCAR2HSD11B1
SCHEMBL9726584 0.77 HMGCR (0.38) HMGCRTSHRNPC1
SCHEMBL10426435 0.76 ALDH1A1 (0.47) HPGDHCAR3HCAR2ALDH1A1
SCHEMBL10612372 0.76 HMGCR (0.37) HMGCRHPGDHCAR3HCAR2ALDH1A1
Hydrochloric Acid SCHEMBL9726849 0.76 HMGCR (0.37) HMGCRTSHRNPC1
SCHEMBL9727161 0.74 HMGCR (0.45) HMGCRTSHR
SCHEMBL9727162 0.74 HMGCR (0.45) HMGCRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5110940-A Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase BRISTOL-MYERS COMPANY (US) 1992-05-05 US disclosed
US-5068346-A Anticholesterol agents BRISTOL-MYERS COMPANY (US) 1991-11-26 US disclosed
US-4897490-A DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE BRISTOL-MEYERS COMPANY (US) 1990-01-30 US disclosed
WO-1988006584-A1 ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS BRISTOL-MYERS COMPANY (US) 1988-09-07 WO disclosed