Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CCR9 | P51686 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005994 | 0.86 | CYP2C8 (0.49) | SRD5A2MAPTRAB9ACYP2C8CCR9 | |
| SCHEMBL25042900 | 0.84 | CYP2C8 (0.48) | SRD5A2MAPTRAB9ACYP2C8CCR9 | |
| SCHEMBL9496067 | 0.84 | SRD5A2 (0.79) | SRD5A2MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL15391539 | 0.82 | CES2 (0.50) | SRD5A2MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL611648 | 0.81 | SRD5A2 (0.70) | SRD5A2MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL10396396 | 0.81 | RECQL (0.53) | SRD5A2MAPTCYP2C8CCR9TSHR | |
| SCHEMBL7995549 | 0.81 | CYP2C8 (0.45) | SRD5A2MAPTRAB9ACYP2C8CCR9 | |
| SCHEMBL11057221 | 0.81 | SRD5A2 (0.68) | SRD5A2CES2CES1ESR1MAPK1 | |
| SCHEMBL8437570 | 0.80 | SRD5A2 (0.96) | SRD5A2MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL610783 | 0.80 | SRD5A2 (0.72) | SRD5A2MAPTRAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |