Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726693 | 0.92 | KDM4E (0.45) | PDE5ALMNAHTTNPSR1THRB | |
| SCHEMBL9726506 | 0.92 | ALDH1A1 (0.44) | PDE5ALMNAHTTTHRBKMT2A | |
| SCHEMBL9726550 | 0.89 | PDE5A (0.41) | PDE5ALMNAHTTNPSR1THRB | |
| SCHEMBL9726673 | 0.88 | BRD4 (0.46) | PDE5AHTTNPSR1KMT2APOLB | |
| SCHEMBL9726545 | 0.88 | PDE5A (0.41) | PDE5ALMNAHTTNPSR1THRB | |
| SCHEMBL9726443 | 0.82 | BACE1 (0.43) | KMT2AALDH1A1APAF1L3MBTL1 | |
| SCHEMBL9726418 | 0.81 | KDM4E (0.46) | PDE5ALMNAHTTTHRBKMT2A | |
| SCHEMBL9726489 | 0.80 | ALDH1A1 (0.46) | PDE5ALMNAHTTTHRBKMT2A | |
| SCHEMBL9726540 | 0.78 | KDM4E (0.44) | LMNAHTTTHRBKMT2AMEN1 | |
| SCHEMBL9726861 | 0.77 | POLB (0.41) | LMNAHTTNPSR1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |