Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726825 | 0.86 | ALDH1A1 (0.39) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL8846423 | 0.81 | ALDH1A1 (0.41) | ESR1ALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL9726750 | 0.81 | ALDH1A1 (0.33) | ESR1ALDH1A1NPC1LMNARAB9A | |
| SCHEMBL9726395 | 0.78 | SRC (0.34) | ESR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9726766 | 0.76 | PTGS2 (0.44) | ALDH1A1RAB9ASMN1; SMN2PKM | |
| SCHEMBL9726776 | 0.76 | PTGS2 (0.44) | ALDH1A1RAB9ASMN1; SMN2PKM | |
| SCHEMBL9726773 | 0.76 | PTGS2 (0.44) | ALDH1A1RAB9ASMN1; SMN2PKM | |
| SCHEMBL10610927 | 0.74 | ESR1 (0.44) | ESR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10610936 | 0.74 | ESR1 (0.44) | ESR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9726576 | 0.71 | HMGCR (0.41) | ESR1ALDH1A1NPSR1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | claimed |
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4939265-A | Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |