SCHEMBL9726561

SCHEMBL9726561

CCOC(=O)CC(=O)CC(O)C(=C(c1ccc(F)cc1)c1ccc(F)cc1)c1nnn(C(C)C)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
HTT P42858 2/20 0.38
HSD17B10 Q99714 2/20 0.38
GAA P10253 2/20 0.36
MEN1 O00255 2/20 0.36
MAPT P10636 2/20 0.36
KMT2A Q03164 2/20 0.36
ADORA2A P29274 2/20 0.36
ADORA3 P0DMS8 1/20 0.36
ADORA1 P30542 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
POLB P06746 1/20 0.34
SLC5A1 P13866 1/20 0.34
SLC5A2 P31639 1/20 0.34
CXCR1 P25024 1/20 0.33
CXCR2 P25025 1/20 0.33
HMGCR P04035 1/20 0.33
CASP3 P42574 1/20 0.33
TRPV1 Q8NER1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10425167 0.87 HMGCR (0.33) ADORA2AADORA1SMN1; SMN2POLBHMGCR
SCHEMBL9726678 0.87 HMGCR (0.38) GAAADORA2AADORA3ADORA1SMN1; SMN2
SCHEMBL9726567 0.84 HMGCR (0.44) KDM4EHPGDHTTHSD17B10GAA
SCHEMBL9726560 0.84 HMGCR (0.44) KDM4EHPGDHTTHSD17B10GAA
SCHEMBL9726520 0.77 ADORA2A (0.39) KDM4EHPGDHSD17B10GAAMEN1
SCHEMBL9726826 0.75 HMGCR (0.54) HMGCR
SCHEMBL9726822 0.75 HMGCR (0.54) HMGCR
SCHEMBL9726586 0.74 HMGCR (0.43) KDM4EHPGDHTTHSD17B10GAA
SCHEMBL9726589 0.74 HMGCR (0.43) KDM4EHPGDHTTHSD17B10GAA
SCHEMBL9726444 0.74 HMGCR (0.46) KDM4EHPGDHTTHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5110940-A Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase BRISTOL-MYERS COMPANY (US) 1992-05-05 US disclosed
US-5068346-A Anticholesterol agents BRISTOL-MYERS COMPANY (US) 1991-11-26 US disclosed
US-4897490-A DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE BRISTOL-MEYERS COMPANY (US) 1990-01-30 US disclosed
WO-1988006584-A1 ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS BRISTOL-MYERS COMPANY (US) 1988-09-07 WO disclosed