SCHEMBL9726800

SCHEMBL9726800

COP(=O)(CC(=O)CC(O)CC(=O)OCc1ccccc1)OC

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
NPC1 O15118 1/20 0.44
MAPK1 P28482 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ABCB1 P08183 1/20 0.43
SLC15A1 P46059 2/20 0.43
MMP9 P14780 1/20 0.41
KYNU Q16719 1/20 0.40
CDC25B P30305 1/20 0.39
SLC6A2 P23975 1/20 0.38
SLC6A3 Q01959 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
ABCC3 O15438 1/20 0.37
NR1I2 O75469 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4465319 0.82 ALDH1A1 (0.56) ALDH1A1MAPK1L3MBTL1KYNUCDC25B
SCHEMBL6153568 0.82 ALDH1A1 (0.63) ALDH1A1MAPK1L3MBTL1ABCB1SLC15A1
SCHEMBL15180189 0.76 ALDH1A1 (0.56) ALDH1A1NPC1MAPK1L3MBTL1ABCB1
SCHEMBL758293 0.76 TSHR (0.47) ALDH1A1MAPK1L3MBTL1KMT2ATDP1
SCHEMBL14994287 0.75 ALDH1A1 (0.54) ALDH1A1MAPK1L3MBTL1ABCB1SLC15A1
SCHEMBL14993140 0.75 ALDH1A1 (0.54) ALDH1A1MAPK1L3MBTL1ABCB1SLC15A1
SCHEMBL25622569 0.74 ALDH1A1 (0.58) ALDH1A1NPC1MAPK1L3MBTL1ABCB1
SCHEMBL5829150 0.74 ALDH1A1 (0.58) ALDH1A1MAPK1L3MBTL1ABCB1SLC15A1
SCHEMBL9634290 0.74 NPC1 (0.51) ALDH1A1NPC1
SCHEMBL18196797 0.74 ALDH1A1 (0.53) ALDH1A1MAPK1L3MBTL1ABCB1SLC15A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5110940-A Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase BRISTOL-MYERS COMPANY (US) 1992-05-05 US disclosed
US-5068346-A Anticholesterol agents BRISTOL-MYERS COMPANY (US) 1991-11-26 US disclosed
US-4897490-A DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE BRISTOL-MEYERS COMPANY (US) 1990-01-30 US disclosed
WO-1988006584-A1 ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS BRISTOL-MYERS COMPANY (US) 1988-09-07 WO disclosed