Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726697 | 0.92 | HMGCR (0.52) | HMGCRGAAALDH1A1HSD11B1 | |
| SCHEMBL9726705 | 0.92 | HMGCR (0.52) | HMGCRGAAALDH1A1HSD11B1 | |
| SCHEMBL9726690 | 0.92 | HMGCR (0.52) | HMGCRGAAALDH1A1HSD11B1 | |
| SCHEMBL9726851 | 0.86 | HMGCR (0.43) | HMGCRPOLBRAB9AALDH1A1RECQL | |
| SCHEMBL9726855 | 0.86 | HMGCR (0.43) | HMGCRPOLBRAB9AALDH1A1RECQL | |
| SCHEMBL9726533 | 0.85 | HMGCR (0.55) | HMGCRALDH1A1 | |
| SCHEMBL9726963 | 0.83 | TCF4 (0.46) | HMGCRMAPK1TDP1KDM4EMAPT | |
| SCHEMBL9727128 | 0.80 | HMGCR (0.53) | HMGCRALDH1A1HSD11B1 | |
| SCHEMBL9726717 | 0.80 | HMGCR (0.53) | HMGCRALDH1A1HSD11B1 | |
| SCHEMBL9727124 | 0.80 | HMGCR (0.53) | HMGCRALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | claimed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | claimed |
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4939265-A | Intermediates and process for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4898949-A | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |