Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.47 |
| ▸ | FABP1 | P07148 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18255822 | 0.82 | CYP11B2 (0.59) | CYP11B2FABP1CSNK1A1CSNK1DGSK3B | |
| SCHEMBL15730519 | 0.81 | CLK4 (0.60) | — | |
| SCHEMBL15730135 | 0.79 | CYP11B2 (0.48) | MKNK1MKNK2CYP11B2 | |
| SCHEMBL7662428 | 0.79 | MKNK1 (0.61) | MKNK1MKNK2ALDH1A1DHODH | |
| SCHEMBL14430133 | 0.79 | CYP11B2 (0.47) | CYP11B2FABP1SLC22A12HSD11B1NPY5R | |
| SCHEMBL27310588 | 0.79 | MKNK1 (0.54) | MKNK1MKNK2CYP11B2FABP1SLC22A12 | |
| SCHEMBL15674589 | 0.78 | NAAA (0.52) | CYP11B2ALDH1A1DHODHFYN | |
| SCHEMBL2757253 | 0.77 | MKNK1 (0.59) | MKNK1MKNK2FABP1DHODH | |
| SCHEMBL15730173 | 0.77 | MKNK1 (0.59) | MKNK1MKNK2ALDH1A1DHODH | |
| SCHEMBL30563610 | 0.77 | MKNK1 (0.58) | MKNK1MKNK2ALDH1A1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1032648-C | Process for preparation of platelet activating factor antagonist | FIZER LTD (GB) | 1996-08-28 | — | — | CN | disclosed |
| US-5149814-A | Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds | PFIZER INC (US) | 1992-09-22 | — | — | US | disclosed |
| US-5120747-A | Antiallergens, antiinflammatory agent | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5070205-A | Chemical intermediate for anticoagulants | PFIZER INC. (US) | 1991-12-03 | — | — | US | disclosed |
| EP-0310386-B1 | 4-ARYL-5-CARBAMOYL-1,4-DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-5063237-A | Antiallergens and antiinflammatory agents | PFIZER INC. (US) | 1991-11-05 | — | — | US | disclosed |
| US-4935430-A | Platelet activating factor antagonists | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| EP-0310386-A2 | 4-Aryl-5-carbamoyl-1,4-dihydropyridines | Pfizer Limited (GB) | 1989-04-05 | — | — | EP | disclosed |