Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.64 |
| ▸ | ACHE | P22303 | 2/20 | 0.63 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | ATF4 | P18848 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727091 | 0.88 | DRD4 (0.70) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL9727169 | 0.86 | MCHR1 (0.59) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL9852064 | 0.86 | MCHR1 (0.66) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL15171517 | 0.86 | DRD4 (0.53) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL16356190 | 0.83 | DRD4 (0.59) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL9727235 | 0.83 | DRD4 (0.58) | MCHR1KCNH2ACHEDRD4CCR3 | |
| SCHEMBL647657 | 0.83 | ACHE (0.59) | MCHR1KCNH2ACHEDRD4KDM4E | |
| SCHEMBL6337974 | 0.82 | MCHR1 (0.79) | MCHR1KCNH2ACHE | |
| SCHEMBL23920321 | 0.82 | ATF4 (0.61) | MCHR1KCNH2ATF4SIGMAR1 | |
| SCHEMBL9727182 | 0.82 | DRD4 (0.64) | MCHR1KCNH2ACHEDRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |