Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.48 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042185 | 0.79 | MMP2 (0.65) | TP53MMP2MEN1KMT2AHTT | |
| SCHEMBL7383735 | 0.79 | MMP2 (0.64) | TP53MMP2GAAMEN1KMT2A | |
| SCHEMBL9727635 | 0.78 | GAA (0.46) | TP53MMP2GAAMEN1KMT2A | |
| SCHEMBL12209246 | 0.77 | HTT (0.66) | DHCR7GAAMEN1KMT2AHTT | |
| SCHEMBL9727557 | 0.77 | GAA (0.44) | TP53MMP2GAA | |
| SCHEMBL9621784 | 0.77 | TSHR (0.61) | TP53MMP2GAAHTTALDH1A1 | |
| SCHEMBL19348522 | 0.77 | DHCR7 (0.59) | DHCR7KMT2AHTTPTGDR2 | |
| SCHEMBL16788114 | 0.76 | HTT (0.69) | DHCR7GAAMEN1KMT2AHTT | |
| SCHEMBL7379601 | 0.75 | MMP2 (0.64) | TP53MMP2GAAMEN1KMT2A | |
| SCHEMBL10702282 | 0.75 | MMP2 (0.64) | TP53MMP2GAAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| US-4990531-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1991-02-05 | — | — | US | disclosed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | disclosed |