Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769108 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2AXLCHRNB4CHRNA3KDR | |
| Biphenyl SCHEMBL27762344 | 0.80 | MAPK1 (0.49) | SMN1; SMN2MAPTKDM4EMAPK1L3MBTL1 | |
| SCHEMBL6771534 | 0.78 | HTR2A (0.38) | SMN1; SMN2NPC1MAPTRAB9AHTR2C | |
| SCHEMBL17838640 | 0.78 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL554697 | 0.78 | KDR (0.43) | SMN1; SMN2KDRNPC1MAPTRAB9A | |
| SCHEMBL4627244 | 0.78 | HTR2C (0.41) | SMN1; SMN2NPC1MAPTRAB9AMAPK1 | |
| SCHEMBL6768059 | 0.78 | KDR (0.43) | SMN1; SMN2KDRNPC1MAPTRAB9A | |
| SCHEMBL11530124 | 0.77 | CHRNB4 (0.51) | SMN1; SMN2CHRNB4CHRNA3NPC1MAPT | |
| SCHEMBL11223071 | 0.74 | — | — | |
| SCHEMBL1427690 | 0.74 | MAOB (0.50) | LRRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4460301-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | Universität zu Köln (DE) | 2024-11-13 | — | — | EP | claimed |
| WO-2023131576-A1 | SIGNALLING-PATHWAY INHIBITOR COMBINATIONS FOR USE IN THE TREATMENT OF CANCER DISEASES | UNIVERSITÄT ZU KÖLN (DE) | 2023-07-13 | — | — | WO | claimed |
| CN-110003200-A | P2X7 regulator | 詹森药业有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-105209464-B | P2X7 modulators | 詹森药业有限公司 | 2019-01-01 | — | — | CN | claimed |
| CN-105209464-A | P2x7 modulators | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | claimed |
| CN-1335836-A | Tricyclic pyrazole derivatives | BASF AG (DE) | 2002-02-13 | — | — | CN | claimed |
| CN-122036691-A | 3-Phenyl-1H-pyrazol-5-alcohol spliced indole derivatives, and preparation method and application thereof | 遵义医药高等专科学校 | 2026-05-15 | — | — | CN | disclosed |
| CN-122036691-A | 3-Phenyl-1H-pyrazol-5-alcohol spliced indole derivatives, and preparation method and application thereof | 遵义医药高等专科学校 | 2026-05-15 | — | — | CN | disclosed |
| CN-122036739-A | 3,4' -Pyrano [2,3-c ] pyrazole spiro oxindole derivative, and preparation method and application thereof | 遵义医药高等专科学校 | 2026-05-15 | — | — | CN | disclosed |
| WO-2024226892-A1 | HYDRAZONE 3H-IMIDAZO(4,5-B)PYRIDINE COMPOUNDS AND USES THEREOF | Verge Analytics, Inc. (US) | 2024-10-31 | — | — | WO | disclosed |
| US-10392397-B2 | Heterocyclic thiosemicarbazone derivatives and their therapeutical applications | NANTBIO, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| CN-110003200-A | P2X7 regulator | 詹森药业有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-105209464-B | P2X7 modulators | 詹森药业有限公司 | 2019-01-01 | — | — | CN | disclosed |
| JP-2001261675-A | MEDICINE CONTAINING PYRAZOLINE DERIVATIVE OR TETRAHYDROPYRIDAZINE DERIVATIVE | MITSUI CHEMICALS INC | 2001-09-26 | — | — | JP | disclosed |
| WO-2001018013-A1 | PRODRUGS FOR LIVER SPECIFIC DRUG DELIVERY | METABASIS THERAPEUTICS, INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2000052015-A2 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS, INC. (US) | 2000-09-08 | — | — | WO | disclosed |
| CN-1015177-B | Method for producing 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS (JP) | 1991-12-25 | — | — | CN | disclosed |
| US-4895947-A | Process for producing 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS, INC. (JP) | 1990-01-23 | — | — | US | disclosed |
| CN-1033994-A | Produce the method for 1-acyl-2-pyrazoline derivative | MITSUI TOATSU CHEMICALS (JP) | 1989-07-19 | — | — | CN | disclosed |
| EP-0322691-A1 | Process for producing 1-acyl-2-pyrazoline derivatives | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392397-B2 | Heterocyclic thiosemicarbazone derivatives and their therapeutical applications | TPMT, MKI67, TST | SMN1; SMN2 2680/4885AXL 3263/4885CHRNB4 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.