Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31402515 | 0.80 | HRH1 (0.43) | ALDH1A1MAPTCYP3A4LMNAHRH1 | |
| SCHEMBL11391091 | 0.75 | USP2 (0.31) | ALDH1A1GAA | |
| SCHEMBL10666116 | 0.73 | CHRNA7 (0.38) | ALDH1A1HSD17B10KDM4EMAPTALOX15 | |
| SCHEMBL57760 | 0.73 | CHRNA7 (0.38) | ALDH1A1HSD17B10KDM4EMAPTALOX15 | |
| SCHEMBL10666122 | 0.73 | CHRNA7 (0.38) | ALDH1A1HSD17B10KDM4EMAPTALOX15 | |
| SCHEMBL24446257 | 0.71 | — | — | |
| SCHEMBL31402488 | 0.69 | HRH1 (0.41) | ALDH1A1KDM4ECYP1A2HRH1SLC22A8 | |
| SCHEMBL16076463 | 0.68 | ALDH1A1 (0.41) | ALDH1A1HSD17B10KDM4EMAPTALOX15 | |
| SCHEMBL5498766 | 0.66 | — | — | |
| SCHEMBL13435199 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106992-A | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same | E. R. SQUIBB & SONS, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0410409-A1 | 3,5-Dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same | E.R. SQUIBB & SONS, INC. (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4970221-A | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same | E. R. SQUIBB & SONS, INC. (US) | 1990-11-13 | — | — | US | disclosed |